- A two-step, one-pot synthesis of diverse N-pyruvoyl amino acid derivatives using the Ugi reaction.
A two-step, one-pot synthesis of diverse N-pyruvoyl amino acid derivatives using the Ugi reaction.
Bioorganic & medicinal chemistry letters (2001-01-02)
M Nakamura, J Inoue, T Yamada
PMID11133097
ABSTRACT
A 100-member combinatorial library of alpha-ketoamides, which was designed to search potent cysteine protease inhibitors, was generated by a parallel solution-phase synthesis. A two-step one-pot synthesis, in which the Ugi reaction followed by pyridinium dichromate (PDC) oxidation was employed in the same reaction vessel, easily afforded the alpha-ketoamides in a short time.
MATERIALS