Determination of phenol and resorcinol using 1,3-dibromo-5,5-dimethylhydantoin (DBH) analogous to the Koppeschaar reaction. Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern, Part 6.

PH. EUR. 1997 determines phenol and resorcinol according to the Koppeschaar reaction using hepatotoxic and environmentally hazardous chloroform. Chlorinated hydrocarbons are not required when applying 1,3-dibromo-5,5-dimethylhydantoin (DBH). The reaction time for phenol can be reduced from 45 to 5 min. Blind values according to PH. EUR. 1997 result a systematic error of about -1.8%.