- [Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane].
[Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane].
Patologicheskaia fiziologiia i eksperimental'naia terapiia (2003-07-04)
M Iu Smakhtin, A I Konoplia, L A Sever'ianova, I A Shveĭnov
PMID12838768
ABSTRACT
10-day intraperitoneal administration of the tripeptie Gly-His-Lys in doses 2.5 and 150 mu/kg raises of mitotic index of hepatocytes in acute toxic damage to the liver. In the dose 1.5 mu/kg this peptie corrects both functional activity of hepatocytes and immunological responsiveness. In a dose of 150 mu/kg the peptie has a more potent immunosuppressive action and deteriorates biochemical indices of blood serum as well as dystrophic changes in the liver.
MATERIALS