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  • [Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane].

[Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane].

Patologicheskaia fiziologiia i eksperimental'naia terapiia (2003-07-04)
M Iu Smakhtin, A I Konoplia, L A Sever'ianova, I A Shveĭnov
ABSTRACT

10-day intraperitoneal administration of the tripeptie Gly-His-Lys in doses 2.5 and 150 mu/kg raises of mitotic index of hepatocytes in acute toxic damage to the liver. In the dose 1.5 mu/kg this peptie corrects both functional activity of hepatocytes and immunological responsiveness. In a dose of 150 mu/kg the peptie has a more potent immunosuppressive action and deteriorates biochemical indices of blood serum as well as dystrophic changes in the liver.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Gly-His-Lys acetate salt, ≥97% (TLC)