[Activity of NO-synthase, apoptosis signal-regulating protein kinase 1, poly-(ADP-ribose)-polymerase, protein kinase C, serine proteinases and DNA fragmentation in rat liver during molybdenum-dependent induction of xanthine oxidase ].

It was discovered that nitric oxide synthase activity and concentration of S-nitrosothiols decreased during molybden-dependent xanthine oxidase activation. The increase of apoptosis signal-regulating kinase 1 activity, with the respected decrease of [table: see text] poly-(ADP-ribose)-polymerase and protein kinase C activities as well as increase of trypsine like serine proteinases activity were observed. No significant changes of DNA fragmentation were revealed.