- Synthesis of isocoumarins via Pd/C-mediated reactions of o-iodobenzoic acid with terminal alkynes.
Synthesis of isocoumarins via Pd/C-mediated reactions of o-iodobenzoic acid with terminal alkynes.
The Journal of organic chemistry (2005-06-04)
Venkataraman Subramanian, Venkateswara Rao Batchu, Deepak Barange, Manojit Pal
PMID15932318
ABSTRACT
The coupling reaction of o-iodobenzoic acid with terminal alkynes by using a catalyst system of 10% Pd/C-Et3N-CuI-PPh3 has been studied in a variety of solvents. 3-Substituted isocoumarins were formed in good yields and with good regioselectivity when the reaction was performed in EtOH.
MATERIALS