CN
- Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots.
Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots.
Bioorganic & medicinal chemistry letters (2005-06-18)
Woo Song Lee, Mi Jeong Kim, Young-Il Beck, Yong-Dae Park, Tae-Sook Jeong
PMID15961310
ABSTRACT
(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA(2) inhibitory activities with IC(50) values of 45.0 and 52.0 microM, respectively.