- Simple synthesis of novel acyclic (e)-bromovinyl nucleosides as potential antiviral agents.
Simple synthesis of novel acyclic (e)-bromovinyl nucleosides as potential antiviral agents.
Nucleosides, nucleotides & nucleic acids (2006-08-12)
Jin Woo Kim, Joon Hee Hong
PMID16901820
ABSTRACT
In these study, novel acyclic (E)-bromovinyl nucleosides were synthesized as potential antiviral agents. The coupling of the allylic bromide 9 with bases (thymine, uracil, 5-fluorouracil, 5-iodouracil, cytosine, adenine) afforded a series of novel acyclic nucleosides. The synthesized compounds were evaluated for their antiviral activity against various viruses such as HIV-1, HSV-1, HSV-2, and HCMV. 5-Iodouracil analogue 19 showed weak anti-HIV-1 activity.
MATERIALS