1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.

1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.

Current drug discovery technologies (2007-11-30)

Huiming Jiang, Shufen Zhang, Qinglin Guan, Chang Chen, Fan Gao, Yang Zhang

ABSTRACT

The inclusion complex between beta-CD and 1-hexadecanol is synthesized and identified via (1)H NMR spectrum. The possible conformation of the inclusion complex is figured out. Via MM2 calculations, the possibility of complexation is verified.

MATERIALS

Product Number

Brand

Product Description

H6800

Sigma-Aldrich

1-Hexadecanol, 95%

W255408

Sigma-Aldrich

1-Hexadecanol, ≥99%

258741

Sigma-Aldrich

1-Hexadecanol, ReagentPlus^®, 99%

68824

Supelco

Cetyl alcohol, analytical standard

PHR1133

Supelco

Cetyl Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material

C0990000

Cetyl alcohol, European Pharmacopoeia (EP) Reference Standard