- Preparation of 2-iodo allylic alcohols from 2-butyn-1,4-diol.
Preparation of 2-iodo allylic alcohols from 2-butyn-1,4-diol.
The Journal of organic chemistry (2008-01-17)
Douglass F Taber, M Inthikhab Sikkander, James F Berry, Kevin J Frankowski
PMID18197678
ABSTRACT
The conversion of 2-butyn-1,4-diol to (Z)-2,4-diiodobut-2-en-1-ol proceeded efficiently using in situ generated trimethylsilyl iodide. Coupling with Grignard reagents and other nucleophiles delivered (2Z)-2-iodo allylic alcohols. The geometry of the products was established by nOe.
MATERIALS