- Synthesis of 3-hydroxypyridines using ruthenium-catalyzed ring-closing olefin metathesis.
Synthesis of 3-hydroxypyridines using ruthenium-catalyzed ring-closing olefin metathesis.
Organic letters (2009-01-02)
Kazuhiro Yoshida, Fumihiro Kawagoe, Kazushi Hayashi, Shingo Horiuchi, Tsuneo Imamoto, Akira Yanagisawa
PMID19117401
ABSTRACT
New synthetic routes to substituted 3-hydroxypyridines 6 are presented. Ring-closing olefin metathesis (RCM)/elimination and RCM/oxidation/deprotection of nitrogen-containing dienes 4 are the key processes of the routes. An application of RCM/oxidation/deprotection to the synthesis of 3-aminopyridine 13f is also described.
MATERIALS