A novel mode of FoxM1 regulation: positive auto-regulatory loop.

Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.