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  • Pyridine N-oxides as ligands in Cu-catalyzed N-arylation of imidazoles in water.

Pyridine N-oxides as ligands in Cu-catalyzed N-arylation of imidazoles in water.

Organic letters (2009-07-04)
Lei Liang, Zhengkai Li, Xiangge Zhou
ABSTRACT

N-arylation of imidazoles with aryl halides catalyzed by a combination of copper(II) sulfate and 1,2-bis(2-pyridyl)-ethane-N,N'-dioxide in water afforded up to 95% yield.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Iodobenzene, 98%
Sigma-Aldrich
Pyridine N-oxide, 95%