- One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates.
One-pot synthesis of 2-pyridones via chemo- and regioselective tandem Blaise reaction of nitriles with propiolates.
The Journal of organic chemistry (2009-09-26)
Yu Sung Chun, Ka Yeon Ryu, Young Ok Ko, Joo Yeon Hong, Jongki Hong, Hyunik Shin, Sang-gi Lee
PMID19778084
ABSTRACT
The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with propiolates in a chemo- and regioselective manner to afford 2-pyridone derivatives in good to excellent yields.
MATERIALS