- Stereocontrolled synthesis of C1-C17 fragment of narasin via a free radical-based approach.
Stereocontrolled synthesis of C1-C17 fragment of narasin via a free radical-based approach.
Organic letters (2009-12-29)
Jean-François Brazeau, Audrey-Anne Guilbault, Jummey Kochuparampil, Philippe Mochirian, Yvan Guindon
PMID20035562
ABSTRACT
An efficient synthesis of the C1-C17 western unit of narasin was achieved from (S)-Roche ester. Highlights in our synthesis include the successful exploitation of three stereoselective sequences of Lewis acid mediated reaction followed by free-radical-based hydrogen transfer.
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