- Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists.
Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists.
Bioorganic & medicinal chemistry letters (2011-02-22)
Malken Bayrakdarian, Joanne Butterworth, Yun-Jin Hu, Vijayaratnam Santhakumar, Mirosław J Tomaszewski
PMID21333534
ABSTRACT
2,4-Diaminopyrimidines derivatives were developed as a novel class of SNSR4 antagonists. Structure activity relationship of the diamino pyrimidine core was explored and a tool compound suitable for target validation was identified.
MATERIALS