- Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene.
Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene.
Chemical communications (Cambridge, England) (2011-06-15)
Alexey B Kornev, Alexander S Peregudov, Vyacheslav M Martynenko, Jan Balzarini, Bart Hoorelbeke, Pavel A Troshin
PMID21666897
ABSTRACT
We report here a facile preparation of highly water-soluble derivatives C(70)[p-C(6)H(4)(CH(2))(n)COOH](8) (n = 2, 3) starting from readily available chlorinated [70]fullerene precursors C(70)Cl(8) and C(70)Cl(10). The synthesized fullerene derivatives showed pronounced antiviral activity in vitro, particularly against human immunodeficiency virus (HIV) and influenza A virus (subtypes H1N1 and H3N2).