- Copper-catalyzed N-arylation of amines with part-per-million catalyst loadings under air at room temperature.
Copper-catalyzed N-arylation of amines with part-per-million catalyst loadings under air at room temperature.
Chemical communications (Cambridge, England) (2011-07-06)
Ruilong Xie, Hua Fu, Yun Ling
PMID21727962
ABSTRACT
An efficient copper-catalyzed method for N-arylation of amines has been developed with part-per-million catalyst loadings at room temperature under air. Reactions of substituted (E)-1-(2-halophenyl)alkanone oximes with aliphatic amines or aromatic amines provided the N-arylation products in good to excellent yields.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Potassium carbonate, puriss., meets analytical specification of Ph. Helv., anhydrous, granulated, 99-101% (calc. to the dried substance)
Sigma-Aldrich
Potassium carbonate, anhydrous, free-flowing, −325 mesh, Redi-Dri™, reagent grade, ≥98%