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  • Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.

Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.

Angewandte Chemie (International ed. in English) (2011-09-10)
Marion Rusch, Tobias J Zimmermann, Marco Bürger, Frank J Dekker, Kristina Görmer, Gemma Triola, Andreas Brockmeyer, Petra Janning, Thomas Böttcher, Stephan A Sieber, Ingrid R Vetter, Christian Hedberg, Herbert Waldmann
PMID21905186
ABSTRACT

Finding the target: activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.