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Merck
CN

Efficient synthesis of scutellarein.

Natural product research (2011-10-20)
Giuliana Righi, Ilaria Proietti Silvestri, Maurizio Barontini, Fernanda Crisante, Andrea Di Manno, Romina Pelagalli, Paolo Bovicelli
ABSTRACT

Scutellarein is a component of Scutellaria, recently known as a potent cytotoxic agent on human leukaemia cells. The aim of this study was the synthesis of scutellarein and its methylated derivative. The new features are the innovating method to afford flavones from flavanones and the A-ring regioselective bromination step that lead to the target molecule by a facile and high-yielding pathway.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Scutellarein, ≥98% (HPLC)