- Enantioselective synthesis of levomilnacipran.
Enantioselective synthesis of levomilnacipran.
Chemical communications (Cambridge, England) (2012-07-07)
Julien Alliot, Edmond Gravel, Florence Pillon, David-Alexandre Buisson, Marc Nicolas, Eric Doris
PMID22767143
ABSTRACT
A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.
MATERIALS