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  • Arylation of 2-substituted pyridines via Pd-catalyzed decarboxylative cross-coupling reactions of 2-picolinic acid.

Arylation of 2-substituted pyridines via Pd-catalyzed decarboxylative cross-coupling reactions of 2-picolinic acid.

Chemical communications (Cambridge, England) (2012-11-23)
Xinjian Li, Dapeng Zou, Faqiang Leng, Chunxia Sun, Jingya Li, Yangjie Wu, Yusheng Wu
ABSTRACT

The novel palladium-catalyzed decarboxylative cross-coupling reactions of 2-picolinic acid with aryl and heteroaryl bromides including benzenes, naphthalenes, pyridines and quinolines for C-C bond formation have been successfully achieved.

MATERIALS
Product Number
Brand
Product Description

Supelco
Naphthalene solution, certified reference material, 5000 μg/mL in methanol
Sigma-Aldrich
2-Picolinic acid, ReagentPlus®, 99%
Sigma-Aldrich
Naphthalene, 99%
Supelco
Naphthalene, analytical standard
Sigma-Aldrich
Naphthalene, suitable for scintillation, ≥99%
Supelco
Naphthalene, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Supelco
Melting point standard 79-81°C, analytical standard