- Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones.
Quinine-thiourea catalyzed enantioselective hydrophosphonylation of trifluoromethyl 2(1H)-quinazolinones.
Chemical communications (Cambridge, England) (2012-12-19)
Hexin Xie, Aiguo Song, Xinshuai Zhang, Xiaobei Chen, Hao Li, Chunquan Sheng, Wei Wang
PMID23248060
ABSTRACT
An organocatalytic enantioselective addition reaction of cyclic ketoimines with phosphites has been developed for the first time. The process, catalyzed by Soós' quinine thiourea, affords synthetically and medicinally interesting enantioenriched trifluoromethyl dihydroquinazolinones in high yields and with high enantioselectivities.