- Prolinethiol ether catalysis in an asymmetric Michael reaction: solvent-free synthesis of functionalized monohaloalkenes.
Prolinethiol ether catalysis in an asymmetric Michael reaction: solvent-free synthesis of functionalized monohaloalkenes.
The Journal of organic chemistry (2013-01-05)
Ai-Bao Xia, Chao Wu, Dan-Qian Xu, Yi-Feng Wang, Xiao-Hua Du, Zhao-Bo Li, Zhen-Yuan Xu
PMID23286458
ABSTRACT
The organocatalytic Michael reaction of ketones with γ-monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with α, β-stereocenters of up to >99% ee.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Diethyl ether, puriss., contains ~5 mg/L 2,6-di-tert.-butyl-4-methylphenol as stabilizer, meets analytical specification of Ph. Eur., BP, ≥99.5% (GC)