- Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.
Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.
European journal of medicinal chemistry (2013-01-05)
Koneni V Sashidhara, Srinivasa Rao Avula, Komal Sharma, Gopala Reddy Palnati, Surendar Reddy Bathula
PMID23287057
ABSTRACT
Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines.