- Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors.
Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors.
Steroids (2013-01-08)
Michal Jurášek, Petr Džubák, David Sedlák, Hana Dvořáková, Marián Hajdúch, Petr Bartůněk, Pavel Drašar
PMID23291595
ABSTRACT
There were synthesized new types of ribbon type steroidal dimers derived from three types of steroidal skeletons (cholic acid, etienic acid, estrone) using Cu(I) catalyzed 1, 3-dipolar cycloaddition reaction. Steroid parts of the molecular "ribbons" are linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)-methyl)pyridine. Compounds synthesized possess different cytotoxic and hormone receptor modulating activities.
MATERIALS
Product Number
Brand
Product Description
Estrone, European Pharmacopoeia (EP) Reference Standard
Cholic acid, European Pharmacopoeia (EP) Reference Standard
Supelco
Estrone solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®