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  • Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

Chembiochem : a European journal of chemical biology (2013-01-31)
Wei Zhang, Jeffrey L Fortman, Jacob C Carlson, Jinyong Yan, Yi Liu, Fali Bai, Wenna Guan, Junyong Jia, Teatulohi Matainaho, David H Sherman, Shengying Li
PMID23362147
ABSTRACT

New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering.