- Cascade synthesis of fenpiprane and related pharmaceuticals via rhodium-catalyzed hydroaminomethylation.
Cascade synthesis of fenpiprane and related pharmaceuticals via rhodium-catalyzed hydroaminomethylation.
Organic letters (2013-02-16)
Shengkun Li, Kexuan Huang, Jiwen Zhang, Wenjun Wu, Xumu Zhang
PMID23410073
ABSTRACT
A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1,1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.
MATERIALS