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  • [The antiaggregant action of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine in in vitro and ex vivo experiments].

[The antiaggregant action of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine in in vitro and ex vivo experiments].

Eksperimental'naia i klinicheskaia farmakologiia (2013-05-02)
Iu S Logvinova, V A Makarov, O N Chupakhin, L P Sidorova, N M Perova, V L Rusinov
ABSTRACT

The influence of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine (H-29) on the platelet aggregation has been studied in experiments on donor plasma in vitro. It is established that H-29 causes a decrease in the platelet interaction induced by ADP and arachidonic acid. The influence of H-29 on platelet aggregation was also studied in ex vivo experiments with intravenous and oral administration, and some parameters of plasmatic hemostasis were evaluated.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Arachidonic acid, from non-animal source, ≥98.5% (GC)
Sigma-Aldrich
Arachidonic acid, >95.0% (GC)
Sigma-Aldrich
Adenosine 5′-diphosphate, ≥95% (HPLC)