- Ames Salmonella/mammalian-microsome testing of peptides and peptide synthesis reagents.
Ames Salmonella/mammalian-microsome testing of peptides and peptide synthesis reagents.
Mutation research (1986-04-01)
J S Allen, J Panfili
PMID3515165
ABSTRACT
The Ames Salmonella/mammalian-microsome assay was used to evaluate the bacterial mutagenicity of 6 bioactive peptides and of 11 chemical reagents used in peptide synthesis. Samples of 2 reagents, bis(2-oxo-3-oxazolidinyl)phosphinic chloride and fluoren-9-ylmethyl chloroformate, showed mutagenic activity with strains TA100 and TA1535, and with TA1537, respectively. No mutagenic activity was found with the bioactive peptides or with the other 9 peptide synthesis reagents.
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