- Total Synthesis of (-)-Reserpine Using the Chiron Approach.
Total Synthesis of (-)-Reserpine Using the Chiron Approach.
The Journal of organic chemistry (1997-02-07)
Stephen Hanessian, Jingwen Pan, Andrew Carnell, Hervé Bouchard, Luc Lesage
PMID11671435
ABSTRACT
A highly stereocontrolled synthesis of ring D/E precursor to reserpine has been developed starting from (-)-quinic acid as a chiral template. The total synthesis of (-)-reserpine is described through the cyclization of an immonium lactam intermediate.