- Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.
Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.
Bioorganic & medicinal chemistry letters (2001-03-30)
S J Conway, J C Miller, P A Howson, B P Clark, D E Jane
PMID11277518
ABSTRACT
The syntheses of a range of ring and alpha-substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included.