- Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring.
Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring.
European journal of medicinal chemistry (2003-02-21)
Angeles Castro, José M Miguel del Corral, Marina Gordaliza, Concepción Grande, Antonia Gómez-Zurita, Dolores García-Grávalos, Arturo San Feliciano
PMID12593917
ABSTRACT
Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). Most of them maintained their cytotoxicity at the microM level.
MATERIALS