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  • Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex.

Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex.

Chemical communications (Cambridge, England) (2011-03-25)
Yu-Jing Lu, Siu-Cheong Yan, Fung-Yi Chan, Lan Zou, Wai-Hong Chung, Wing-Leung Wong, Bin Qiu, Ning Sun, Pak-Ho Chan, Zhi-Shu Huang, Lian-Quan Gu, Kwok-Yin Wong
PMID21431154
ABSTRACT

A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective response of the fluorescent probe arises from end-stack binding to G-quadruplex.