Accelerated tumor induction by distal esophageal constriction in the rat under the influence of N-ethyl-N-butyl-nitrosamine.

When given N-ethyl-N-butyl-nitrosamine, which was added to the drinking water, a statistically significantly greater number of esophageal papillomas developed in rats with an operatively produced stenosis of the distal esophagus than in control rats without stenosis. The tumor induction occurred earlier in the rats that had undergone surgery, and the preferred site was in the area of the stenosis.