- Antileishmanial activity of the ether phospholipid ilmofosine.
Antileishmanial activity of the ether phospholipid ilmofosine.
Transactions of the Royal Society of Tropical Medicine and Hygiene (1993-03-01)
S L Croft, R A Neal, E A Thornton, D B Herrmann
PMID8337733
ABSTRACT
The ether phospholipid ilmofosine (BM 41.440) was active in vitro against amastigotes of Leishmania donovani and an antimony-resistant line of L. infantum in mouse peritoneal macrophages with ED50 values of 3.7 microM and 3.5 microM respectively. Ilmofosine was also active against L. donovani in BALB/c mice following oral and subcutaneous dosing, with an ED50 value of 10.5 mg/kg x 5 by the oral route.