- Molecular physiology of renal p-aminohippurate secretion.
Molecular physiology of renal p-aminohippurate secretion.
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society (2001-07-10)
G Burckhardt, A Bahn, N A Wolff
PMID11443229
ABSTRACT
Renal proximal tubules secrete various organic anions, including drugs and p-aminohippurate (PAH). Uptake of PAH from blood into tubule cells occurs by exchange with intracellular alpha-ketoglutarate and is mediated by the organic anion transporter 1. PAH exit into tubule lumen is species specific and may involve ATP-independent and -dependent transporters.
MATERIALS