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  • [Effect of various specific agents on the heat stability of human serum albumin].

[Effect of various specific agents on the heat stability of human serum albumin].

Ukrainskii biokhimicheskii zhurnal (1978) (1993-09-01)
T V Semenova, G Iu Azhitskiĭ, V V Sarnatskaia, V G Nikolaev
ABSTRACT

Effect of lipoic acid, 5,5-dithiobis-2-nitrobenzoic acid, monoiodoacetic acid and cystine on thermal stability of human serum albumin was studied by differential scanning calorimetry and electrophoretic methods. Quantitative estimation of the protective effect of these reagents on resistance of 5% solutions of albumin to the temperature influence was studied. It is concluded that all the compounds used protect albumin from polymerization at heating.

MATERIALS
Product Number
Brand
Product Description

Supelco
(R)-(+)-α-Lipoic acid, analytical standard
Sigma-Aldrich
(R)-(+)-α-Lipoic acid, ≥98.0% (HPLC)