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  • Cucurbitane-type triterpenoids from the fruit pulp of Momordica charantia.

Cucurbitane-type triterpenoids from the fruit pulp of Momordica charantia.

Natural product communications (2013-02-19)
Yun-Wen Liao, Chiy-Rong Chen, Yueh-Hsiung Kuo, Jue-Liang Hsu, Wen-Ling Shih, Hsueh-Ling Cheng, Tzou-Chi Huang, Chi-I Chang
PMID23413554
ABSTRACT

Three new cucurbitane-type triterpenoids, 5beta,19-epoxy-23(R)-methoxycucurbita-6,24-dien-3beta-ol (1), 5beta,19-epoxy-23(S)-methoxycucurbita-6,24-dien-3beta-ol (2), and 3beta-hydroxy-23(R)-methoxycucurbita-6,24-dien-5beta,19-olide (3), were isolated from the fruit pulp of Momordica charantia. Their structures were established on the basis of extensive NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS studies. Compound 1 exhibited cytotoxic activity against the SK-Hep 1 cell line.