CN
- Highly N2-selective coupling of 1,2,3-triazoles with indole and pyrrole.
Highly N2-selective coupling of 1,2,3-triazoles with indole and pyrrole.
Chemistry (Weinheim an der Bergstrasse, Germany) (2014-01-01)
Jian Wen, Li-Li Zhu, Qing-Wei Bi, Zhu-Qing Shen, Xiao-Xiao Li, Xin Li, Zhen Wang, Zili Chen
PMID24375713
ABSTRACT
Hydrogen-bond mediated coupling of 1,2,3-triazoles to indoles and pyrroles results in N2 selective functionalization of the triazole moiety in moderate to excellent yields. The reaction was tolerant of un-, mono- and disubstituted triazoles and was applied to synthesize tryptophan derived fluorescent amino acids.
MATERIALS