[Secondary osteoporosis or secondary contributors to bone loss in fracture. Bone metabolism and heavy metals (cadmium and iron) ].

Fibroblast growth factor 23 (FGF23) is a bone-derived phosphaturic factor and is known to regulate blood inorganic phosphate (Pi) . Cadmium (Cd) , a toxic transition metal, which is widely used in industry, affecting human health and through occupational and environmental exposure. Phosphaturia has been documented following Cd exposure in both human and experimental animals. In animal study, Cd administration increases serum FGF23 concentrations. Moreover, medication such as infusion of select iron-containing compounds increases serum FGF23 concentrations, with patients developing hypophosphatemia. Thus, a relationship between metal ion (Cd and Fe) and FGF23 metabolic pathway has been proposed.