- Modification of Catharanthus roseus alkaloids: a lactone derived from 17-deacetylvinblastine.
Modification of Catharanthus roseus alkaloids: a lactone derived from 17-deacetylvinblastine.
Planta medica (1989-08-01)
A De Bruyn, M Verzele, J P Dejonghe, K S Bhushana Rao, M P Collard, A Trouet, J Hannart
PMID2813571
ABSTRACT
A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.