- Cryptosporioptide: a bioactive polyketide produced by an endophytic fungus Cryptosporiopsis sp.
Cryptosporioptide: a bioactive polyketide produced by an endophytic fungus Cryptosporiopsis sp.
Phytochemistry (2013-05-07)
Muhammad Saleem, Muhammad Imran Tousif, Naheed Riaz, Ishtiaq Ahmed, Barbara Schulz, Muhammad Ashraf, Rumana Nasar, Gennaro Pescitelli, Hidayat Hussain, Abdul Jabbar, Nusrat Shafiq, Karsten Krohn
PMID23642454
ABSTRACT
An antibiotic polyketide, Cryptosporioptide (1) was isolated from the culture extract of the endophytic fungus Cryptosporiopsis sp. The structure of Cryptosporioptide has been established with the help of 1D ((1)H, (13)C), 2D NMR (HSQC, HMBC, COSY, NOESY) techniques and mass spectrometry (FABMS, HRFABMS). The absolute configuration was established by means of electronic circular dichroism (ECD). Cryptosporioptide exhibited both lipoxygenase inhibitory and anti-Bacillus megaterium activities.