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  • Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands.

Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands.

Bioorganic & medicinal chemistry letters (2005-12-21)
Raman K Bakshi, Qingmei Hong, Rui Tang, Rubana N Kalyani, Tanya Macneil, David H Weinberg, Lex H T Van der Ploeg, Arthur A Patchett, Ravi P Nargund
PMID16364639
ABSTRACT

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.