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  • Late ureteral obstruction after injection of dextranomer/hyaluronic acid copolymer.

Late ureteral obstruction after injection of dextranomer/hyaluronic acid copolymer.

Urology (2014-01-15)
Samuel Christen, Mario Mendoza, Rita Gobet, Peter Bode, Daniel Weber
ABSTRACT

Various biological and artificial materials have been introduced for endoscopic treatment of vesicoureteral reflux. Over the past years, dextranomer combined with hyaluronic acid (Dx/Ha) has been established as the most commonly used tissue-augmenting substance for subureteral injection because of its biocompatibility. Nevertheless, the histopathologic analysis of failed Dx/Ha injections showed changes in consistency and volume of the deposit and granulomatous reactions of the adjacent tissue. We report a case of late-onset obstruction 2 years after the injection of Dx/Ha. In the current literature, this potential long-term complication is hardly mentioned.

MATERIALS
Product Number
Brand
Product Description

Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, suitable for gel permeation chromatography (GPC), Mw 25,000
Sigma-Aldrich
Dextran solution from Leuconostoc mesenteroides, 20 % (w/w) (Autoclaved)
Sigma-Aldrich
Hyaluronic acid sodium salt from bovine vitreous humor
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 9,000-11,000
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 1,500,000-2,800,000
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Dextran from Leuconostoc mesenteroides, average mol wt 15,000-30,000
Supelco
Dextran, analytical standard, suitable for gel permeation chromatography (GPC), Set Mp 1,000-400,000
Dextran 4 for calibration, Dextran 4 European Pharmacopoeia (EP) Reference Standard
Dextran 1, Dextran 1 European Pharmacopoeia (EP) Reference Standard
Dextran Vo, Dextran Vo European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 60,000-76,000
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr ~40,000
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 35,000-45,000
Supelco
Dextran, analytical standard, 150,000
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Dextran from Leuconostoc spp., Mr ~100,000
Supelco
Dextran, analytical standard, 670,000
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr 15,000-25,000
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Dextran, enzymatic synth.
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, suitable for gel permeation chromatography (GPC), Mw 50,000
Supelco
Dextran, analytical standard, 25,000
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 150,000
Supelco
Dextran, analytical standard, 12,000
Supelco
Dextran, analytical standard, 410,000
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Dextran from Leuconostoc spp., Mr 450,000-650,000
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, suitable for gel permeation chromatography (GPC), Mw 5,000
Supelco
Dextran, analytical standard, 1,000
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr ~6,000
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, Mr ~200,000
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr ~70,000
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, suitable for gel permeation chromatography (GPC), Mw 670,000