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Merck
CN
  • Prevention of haemorrhagic disease of the newborn. Routine vitamin K1 administration is justified.

Prevention of haemorrhagic disease of the newborn. Routine vitamin K1 administration is justified.

Prescrire international (1999-05-26)
ABSTRACT

(1) Haemorrhagic disease of the newborn is due to vitamin K deficiency. Although rare, it is life-threatening and can have neurological sequelae. Prevention is based on routine vitamin K1 administration at birth. (2) The oral route is suitable for healthy term neonates, but dosing must be repeated if the infant is mainly breastfed. (3) The intramuscular route is reserved for neonates at risk (prematurity, neonatal disease, maternal treatment with antiepileptics or antibiotics), because of a possible risk of carcinogenicity.

MATERIALS
Product Number
Brand
Product Description

Supelco
Phylloquinone (K1), analytical standard
Sigma-Aldrich
Vitamin K1, viscous liquid
Phytomenadione, European Pharmacopoeia (EP) Reference Standard
Supelco
Phytonadione, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Vitamin K1, BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers