Recent biomimetic and organocatalytic syntheses of alpha-tocopherol.

Recent biomimetic and organocatalytic syntheses of alpha-tocopherol.

Chimia (2010-12-09)

Antoinette Chougnet, Kegang Liu, Wolf D Woggon

ABSTRACT

We report here on our efforts to develop new strategies for the synthesis of alpha-tocopherol, the biologically most significant member of the vitamin E family. This review comprises five new methods to generate the chiral chromane of alpha-tocopherol with overall up to 29% yield from commercially available material and up to 94% de.

MATERIALS

Product Number

Brand

Product Description

T3634

Sigma-Aldrich

(+)-α-Tocopherol, from vegetable oil, Type V, ~1000 IU/g

T1539

Sigma-Aldrich

(+)-α-Tocopherol, Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g