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Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance.

Cobalt stress in Escherichia coli and Salmonella enterica: molecular bases for toxicity and resistance.

Metallomics : integrated biometal science (2011-09-29)

F Barras, M Fontecave

ABSTRACT

Cobalt (Co) is present in trace amounts in the environment but it can be toxic when it accumulates in cells. The question of how Co produces its toxic effects and how living organisms protect themselves from, and resist to, such a stress remains to be clarified. Studies pertaining to these issues were recently carried out in Escherichia coli and Salmonella enterica. Iron-sulfur proteins were identified as primary targets of Co ions. Perturbation of iron homeostasis, oxidative stress and possible effects on sulfur assimilation were noticed. Cells were found to respond by up-regulating genes involved in the biosynthesis of Fe-S clusters as well as genes involved in Co efflux. These data are summarized in this review article to provide a preliminary general view of Co toxicity mechanisms in these two bacterial models.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

Sigma-Aldrich

Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, ≥99.99%

Sigma-Aldrich

Cobalt, wire, diam. 1.0 mm, 99.995% trace metals basis

Sigma-Aldrich

Cobalt, granular, 99.99% trace metals basis

Cobalt, foil, 25x25mm, thickness 1.0mm, as rolled, 99.99+%

Cobalt, foil, not light tested, 50x50mm, thickness 0.025mm, 99.9%

Sigma-Aldrich

Cobalt, pieces, 99.5% trace metals basis

Sigma-Aldrich

Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%

Cobalt, wire reel, 0.5m, diameter 0.5mm, hard, 99.99+%

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

Cobalt, wire reel, 2m, diameter 0.05mm, hard, 99.9%

Cobalt, foil, not light tested, 25x25mm, thickness 0.008mm, 99.9%

Cobalt, foil, 8mm disks, thickness 0.025mm, 99.9%

Cobalt, foil, 8mm disks, thickness 0.007mm, 99.9%

Cobalt, foil, 8mm disks, thickness 0.05mm, as rolled, 99.99+%

Cobalt, foil, 6mm disks, thickness 0.006mm, 99.9%

Cobalt, foil, not light tested, 25x25mm, thickness 0.005mm, 99.9%

Cobalt, foil, not light tested, 50x50mm, thickness 0.0125mm, 99.9%

Cobalt, foil, 4mm disks, thickness 0.125mm, annealed, 99.9%

Cobalt, foil, 4mm disks, thickness 0.025mm, 99.9%

Cobalt, microfoil, disks, 10mm, thinness 0.25μm, specific density 222μg/cm², permanent mylar 3.5μm support, 99.9%

Cobalt, foil, 6mm disks, thickness 0.007mm, 99.9%

Cobalt, foil, 8mm disks, thickness 0.25mm, as rolled, 99.9%

Cobalt, foil, 8mm disks, thickness 0.05mm, as rolled, 99.9%

Cobalt, foil, light tested, 25x25mm, thickness 0.015mm, 99.9%

Cobalt, wire reel, 0.025m, diameter 2.0mm, hard, 99.99+%

Cobalt, foil, light tested, 100x100mm, thickness 0.05mm, as rolled, 99.99+%

Cobalt, foil, 6mm disks, thickness 0.015mm, 99.9%