Acute massive pulmonary embolism associated with olanzapine therapy and no significant personal history in a young male--case report and literature review.

We report the case of a 28 years old, non-smoker male with a massive pulmonary embolism and left pleural effusion associated and probably induced by olanzapine 10 mg once daily in the previous 4 months, completely recovered after 18 days of stopping the antipsychotic and trombolytic treatment. Thrombotic events have been reported with the use of antipsychotic compounds, although the incidence, predisposing factors, and biological mechanisms associated with these events in psychiatric patients are subject to debate.