Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)

Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw

PMID22099160

ABSTRACT

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

MATERIALS

Product Number

Brand

Product Description

GF03467202

Aluminum, honeycomb, 300x300mm, thickness 52.3mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin glass fiber 0.75mm, 99.9%

326887

Sigma-Aldrich

Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis

433705

Sigma-Aldrich

Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

GF36586042

Aluminum, rod, 100mm, diameter 20.0mm, as drawn, 99.999%

GF95825403

Aluminum, sphere, 100pcs, diameter 3.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF72709151

Aluminum, rod, 100mm, diameter 28mm, as drawn, 99.999%

GF12712610

Aluminum, sphere, 100pcs, diameter 6.0mm, 99%

GF19654803

Aluminum, rod, 200mm, diameter 5.0mm, as drawn, 99.999%

GF27426944

Aluminum, insulated wire, 2m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%

GF16562246

Aluminum, tube, 500mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%

GF85927056

Aluminum, microleaf disks, 25mm, thinness 0.5μm, specific density 120.6μg/cm², removable support, 99.999%

GF28125390

Aluminum, tube, 200mm, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, as drawn, 99.5%

GF10105524

Aluminum, microleaf disks, 25mm, thinness 0.25μm, specific density 68.8μg/cm², removable support, 99.999%

GF85983205

Aluminum, microleaf disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm², removable support, 99.999%

GF52495500

Aluminum, tube, 0.1m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%

GF94706354

Aluminum, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF48798309

Aluminum, rod, 100mm, diameter 6.0mm, as drawn, 99.999%

GF84145462

Aluminum, microfoil, disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm², permanent mylar 3.5μm support, 99.999%

GF62984346

Aluminum, tube, 2m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%

GF72881297

Aluminum, microfoil, disks, 50mm, thinness 1.0μm, specific density 269.9μg/cm², permanent mylar 3.5μm support, 99.999%

GF98025239

Aluminum, tube, 100mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%

GF86733726

Aluminum, rod, 200mm, diameter 15.0mm, as drawn, 99.999%

GF02208923

Aluminum, tube, 200mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%

GF73255237

Aluminum, rod, 200mm, diameter 20.0mm, as drawn, 99.999%

GF87559420

Aluminum, tube, 0.5m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%

GF49694743

Aluminum, tube, 100mm, outside diameter 0.6mm, inside diameter 0.3mm, wall thickness 0.15mm, as drawn, 99.5%

GF93309037

Aluminum, tube, 200mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%

GF06197014

Aluminum, rod, 200mm, diameter 10.0mm, as drawn, 99.999%

GF72634103

Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%

GF12154171

Aluminum, sphere, 200pcs, diameter 6.0mm, 99%