- Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.
Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.
Cancer letters (2012-10-04)
Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker
PMID23032720
ABSTRACT
One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.
MATERIALS
Product Number
Brand
Product Description
Platinum, foil, 0.1m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%
Platinum, tube, 100mm, outside diameter 0.6mm, inside diameter 0.5mm, wall thickness 0.05mm, as drawn, 99.95%
Platinum, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%
Platinum, foil, 0.5m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%
Platinum, foil, 50x50mm, thickness 0.1mm, as rolled, 99.99+%
Platinum, foil, 0.05m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%
Platinum, wire reel, 0.1m, diameter 0.5mm, as drawn, 99.99+%
Platinum, wire reel, 0.1m, diameter 0.125mm, as drawn, 99.95%
Platinum, foil, 10mm disks, thickness 0.125mm, as rolled, 99.95%
Platinum, foil, 0.5m coil, thickness 0.025mm, coil width .85mm, as rolled, 99.95%
Platinum, foil, 0.05m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%
Platinum, wire reel, 0.5m, diameter 0.001mm, wollaston, 99.9%
Platinum, foil, 6mm disks, thickness 0.0125mm, as rolled, 99.95%
Platinum, foil, 8mm disks, thickness 0.0075mm, as rolled, 99.95%
Platinum, foil, 8mm disks, thickness 0.025mm, as rolled, 99.99+%
Platinum, wire reel, 0.1m, diameter 0.3mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, light tested, 50x50mm, thickness 0.05mm, as rolled, 99.95%
Platinum, foil, 10mm disks, thickness 0.0075mm, as rolled, 99.95%
Platinum, foil, not light tested, 25x25mm, thickness 0.0075mm, as rolled, 99.95%
Platinum, wire reel, 10m, diameter 0.025mm, hard, 99.9%
Platinum, foil, not light tested, 50x50mm, thickness 0.005mm, as rolled, 99.95%